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Curcumin and melanoma
Can a spice help fight cancer?
7/11/05
The Asian spice that gives curried rice its bright yellow color could someday provide researchers with a new way to fight skin cancer. Small doses of curcumin, a spice ground from the turmeric root and a common ingredient in curry, not only stopped the growth of melanoma cells in the lab but also caused the cells to self-destruct, say researchers from the University of Texas's M. D. Anderson Cancer Center in Houston.
The researchers tested curcumin on lab-grown melanoma cells to see if the spice could stop the cells from surviving and reproducing. The more curcumin they added to the melanoma, the more cells died. Unlike normal cells, cancer cells grow uncontrollably and do not self-destruct. Increased doses of curcumin also stopped the melanoma cells from reproducing.
One coauthor of the paper, which will be published in the August 15 issue of the journal Cancer, Bharat Aggarwal, said curcumin is intriguing to researchers because of its low toxicity. While most forms of chemotherapy cause serious adverse reactions in cancer patients, studies have shown that people can tolerate large amounts of curcumin with no ill effects. Curcumin also works as an antioxidant and an anti-inflammatory agent.
"People from countries like India have been taking it for thousands of years," says Aggarwal. "It is well tolerated. Here is a completely nontoxic anti-inflammatory agent."
Doctors diagnose roughly 53,600 people with melanoma each year. The cancerous cells develop as irregularly shaped and colored moles on the surface of the skin. The cancer resists many chemotherapy treatments and can metastasize, spreading to other organs in the body.
Aggarwal and his colleagues believe that curcumin blocks the signals a cancer cell needs to survive. David Fisher, director of the melanoma program at the Dana Farber Cancer Institute, said that looking at how curcumin blocks these signals was one of the more important discoveries in this paper.
But is Indian food really a cure for cancer? While this laboratory evidence is interesting, researchers say, it doesn't prove that curcumin will help fight cancer in humans. "It's way in its infancy," Allan Halpern, chief of dermatology at Memorial Sloan-Kettering Cancer Center, says of the research. "The problem is that, to date, we do not have is clinical data to support the fact that using these agents as a chemo-preventative strategy is effective."
In the meantime, Aggarwal and his colleagues continue to tests curcumin on a wide variety of cancers, including breast cancer. "Curcumin is a perfect alternative [to chemotherapy], but we have to prove that it works," he says.
Find out more: The National Cancer Institute has an extensive web page on melanoma.
Abstract online: www3.interscience.wiley.com
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Saturday 30 July 2011
What is Curcumin?
Curcumin - What is Curcumin?
news-medical.net/health/Curcumin-What-is-Curcumin.aspx
Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae).
The other two curcuminoids are desmethoxycurcumin and bis-desmethoxycurcumin. The curcuminoids are polyphenols and are responsible for the yellow color of turmeric. Curcumin can exist in at least two tautomeric forms, keto and enol. The enol form is more energetically stable in the solid phase and in solution.
Curcumin can be used for boron quantification in the so-called curcumin method. It reacts with boric acid forming a red colored compound, known as rosocyanine.
Curcumin is brightly yellow colored and may be used as a food coloring. As a food additive, its E number is E100 .
This article is licensed under the Creative Commons Attribution-ShareAlike License. It uses material from the Wikipedia article on "Curcumin" All material adapted used from Wikipedia is available under the terms of the Creative Commons Attribution-ShareAlike License. Wikipedia® itself is a registered trademark of the Wikimedia Foundation, Inc.
The other two curcuminoids are desmethoxycurcumin and bis-desmethoxycurcumin. The curcuminoids are polyphenols and are responsible for the yellow color of turmeric. Curcumin can exist in at least two tautomeric forms, keto and enol. The enol form is more energetically stable in the solid phase and in solution.
Turmeric Roots: Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric
Curcumin is brightly yellow colored and may be used as a food coloring. As a food additive, its E number is E100 .
Further Reading
This article is licensed under the Creative Commons Attribution-ShareAlike License. It uses material from the Wikipedia article on "Curcumin" All material adapted used from Wikipedia is available under the terms of the Creative Commons Attribution-ShareAlike License. Wikipedia® itself is a registered trademark of the Wikimedia Foundation, Inc.
Recent Curcumin News
- Majority of cancers are due to epigenetic influencesDr. Ajay Goel, Ph.D., Director of Epigenetics and Cancer Prevention at the Gastrointestinal Research Center at Baylor University Medical Center in Dallas, TX, has announced plans for a series of upcom...
- Multiple toxic mechanisms link elevated iron, copper levels in the brain and extensive DNA damageNo one knows the cause of most cases of Alzheimer's, Parkinson's and other neurodegenerative disorders. But researchers have found that certain factors are consistently associated with these debilitat...
- Curcumin compound can help head and neck cancer cells overcome resistance to chemotherapy drugsA primary reason that head and neck cancer treatments fail is the tumor cells become resistant to chemotherapy drugs. Now, researchers at the University of Michigan Comprehensive Cancer Center have fo...
- Basic Yellow 1 dye extends lifespan in healthy nematodes, slows Alzheimer's disease-like pathology in wormsBasic Yellow 1, a dye used in neuroscience laboratories around the world to detect damaged protein in Alzheimer's disease, is a wonder drug for nematode worms. In a study appearing in the March 30, on...
- UCLA researchers identify new biomarker that can help track amyloid beta in Alzheimer'sUCLA researchers have identified a new biomarker that could help them track how effectively the immune system is able to clear the brain of amyloid beta, which forms the plaques considered one of the ...
ScienceDaily: Alzheimer's News
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How a Gene Linked to Both Alzheimer's Disease and Type 2 Diabetes Works
July 28, 2011 — Researchers have identified how a gene for a protein that can cause type 2 diabetes, also possibly kills nerve cells in the brain, thereby contributing to Alzheimer's ... > full story
Vitamin D, Curcumin May Help Clear Amyloid Plaques Found In Alzheimer's Disease
Vitamin D, Curcumin May Help Clear Amyloid Plaques Found In Alzheimer's Disease
ScienceDaily (July 16, 2009) — UCLA scientists and colleagues from UC Riverside and the Human BioMolecular Research Institute have found that a form of vitamin D, together with a chemical found in turmeric spice called curcumin, may help stimulate the immune system to clear the brain of amyloid beta, which forms the plaques considered the hallmark of Alzheimer's disease.
ScienceDaily (July 16, 2009) — UCLA scientists and colleagues from UC Riverside and the Human BioMolecular Research Institute have found that a form of vitamin D, together with a chemical found in turmeric spice called curcumin, may help stimulate the immune system to clear the brain of amyloid beta, which forms the plaques considered the hallmark of Alzheimer's disease.
Friday 29 July 2011
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TESTS OF TEN RED YEAST RICE SUPPLEMENTS BY CONSUMERLAB.COM REVEAL SIGNIFICANT STATIN LEVELS, BUT SOME PILLS CONTAMINATED
WHITE PLAINS, NEW YORK — JULY 1, 2008ConsumerLab.com announced today that its tests of ten red yeast rice supplements revealed levels of cholesterol-lowering statin compounds varying by more than 100-fold, with some supplements providing as much as prescription medication and others containing very little. A potentially toxic contaminant, citrinin, was found in four of the products, with highest levels in a supplement sold by a national pharmacy chain.
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Researchers have found wide variations in the amount of active compounds known as monacolins -- related to prescription drugs called statins -- in different brands of the popular dietary supplement red yeast rice.
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WHITE PLAINS, NEW YORK — JULY 1, 2008ConsumerLab.com announced today that its tests of ten red yeast rice supplements revealed levels of cholesterol-lowering statin compounds varying by more than 100-fold, with some supplements providing as much as prescription medication and others containing very little. A potentially toxic contaminant, citrinin, was found in four of the products, with highest levels in a supplement sold by a national pharmacy chain.
Red yeast rice naturally contains the cholesterol-lowering statin compound lovastatin, the active ingredient in prescription Mevacor. Labels on red yeast rice products, however, generally do not disclose their lovastatin content due to concern that the supplement will be considered a drug by the FDA and removed from the market. This makes it difficult for consumers and doctors to assess and compare red yeast rice supplements, although they remain widely used.
http://www.consumerlab.com/news/Red_Yeast_Rice_Supplements_Tests_Comparison_Lovastatin/7_1_2008/
Red Yeast Rice May Lower Cholesterol
Study Shows Supplement Reduces LDL Cholesterol Levels
By Salynn Boyles
WebMD Health News
Reviewed by Louise Chang, MD
June 17, 2009 -- By some estimates, as many as 10% of people who take cholesterol-lowering statins experience troubling muscle pain, and many stop taking the drugs because of it.
Now a new study suggests that a dietary supplement sold in nutrition centers and grocery stores may be a useful alternative to statins for some.
http://www.webmd.com/cholesterol-management/news/20090617/red-yeast-rice-may-lower-cholesterol
Physician Naturals Premium Organic Red Yeast Rice is a pharmaceutical grade super supplement providing 600mg in a highly absorbable vegetarian capsule. Small scale studies using pharmaceutical-grade red rice yeast have continued to demonstrate efficacy, highest statin levels and safety for lowering cholesterol levels.
PhysicianNaturals SimplyPure Red Yeast Rice is produced entirely in the USA.
Every batch is tested by an independent lab and Certificate of Analysis enclosed with every order, unprecedented in the health food industry < Click to See Certificate of Analysis >
PhysicianNaturals.com
Monday 27 June 2011
Resveratrol Acai RedYeastRice CoQ10 MilkThistle Vitamin B12
Resveratrol Acai RedYeastRice CoQ10 MilkThistle Vitamin B12
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The cost is $23.50 for a bottle of 60 ~ price is reduced if a carton of 12 is purchased.
Hope This Helps Someone
Anyway, I decided that I wasn't going to let it go to waste. Although I had my RA pain under control, I though I would take this and see what happened.
My results were very interesting. I'm at that age where I had started getting "hot flashes" and after 3 days on Curamin they completely disappeared. WHAT ARE RELIEF!
I don't take the curamin all the time, but anytime I experience a hot flash I go back to taking Curamin, I swear by it to control hot flashes, haven't noticed other benefits but I don't usually take it long enough for it to do alot. (I have a strong aversion to taking pills).
Just to let you know that Market America is known for their quality products and they have a product called Curcumin Extreme. You can access it through www.marketamerica.com/headedtotop It is listed under Health and Nutrition and then general health. I also wanted to tell you about a product called OPC-3 that has changed my life. It attacks inflamation in the body and can be used to help arthritis, lupus, rheumatoid a. Also proven effective on asthma, allergies and even autism. If you do a search on the web, you will find testimonials supporting effectiveness. It is under Isotonix brand name on the same web site. I have 4 severly injured discs from a car accident and osteo. Took away so much pain and stiffness. Helped to cut down on pain killers. Check it out and if you have any questions, you can email me at Headedtotop@aol.com. Good luck to you!
from New Chapter has turmeric in it, but didn't help me as much as the pure curcuminoid tablets (1,000mg ach)2x daily with meals. Vibrant Health is the company producing this curcuminoid. I would really like to find the actual brand MD Anderson used.I have shared this information with my doctor.